Cisplatin gsh
WebEbselen is a seleno-organic compound with documented cytoprotective properties. Little work has been done, however, demonstrating ebselen's cytoprotective prop WebAug 8, 2010 · Cisplatin can bind to the thiol group of intracellular glutathione (GSH) and this reaction is considered important for the inactivation of cisplatin . However, Gibson and coworkers recently suggested that binding of cisplatin to GSH is not the most important cellular interaction for inactivation ( 17 ).
Cisplatin gsh
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WebNov 27, 2024 · It is well established that one of the main factors that promote intracellular cisplatin detoxification is GSH, since it can bind covalently to the drug and prevent it to … Webized GSH concentration as compared to cisplatin alone (table 2). The renal GSH and oxidized GSH concentrations in lipoic acid alone treated group were 19.93”2.39 and 1.14”0.12 nmoles/mg protein which were close to control values. Superoxide dismutase activity in the kidney significantly decreased (62% of control) in cisplatin-treated rats ...
WebFeb 1, 2012 · Recently, Volckova, et al. [17] used a variety of physical techniques to show that GSH rapidly reduces iproplatin, 2, to produce cis -di (isopropylamine)chloro-glutathionatoplatinum (II) which has the thiolate of a GSH molecule bound to Pt (II). Web(GSH) transferase activity of GST P1-1. Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity. Furthermore, it is well known that GST P1-1 binding to the c-Jun N-terminal kinase (JNK) inhibits JNK phosphory-
Webized GSH concentration as compared to cisplatin alone (table 2). The renal GSH and oxidized GSH concentrations in lipoic acid alone treated group were 19.93”2.39 and … WebGSH reacts with hydrogen peroxide and organic peroxides, the harmful byproducts of aerobic life. GSH is also essential for maintaining the normal structure of red blood cells.4 In the presence of cisplatin, GSH forms a 2:1 (GSH:platinum) complex …
WebOxidative stress caused by cisplatin, evidenced by increases in kidney tissues malondialdehyde (MDA) content, cytochrome P450 E1 (CYP2E1), renal 4-hydroxynonenal (4-HNE) levels and decreases of glutathione (GSH) and superoxide dismutase (SOD) contents, was significantly ameliorated by AGBE pretreatment.
WebApr 25, 2024 · Cisplatin accumulates in the mitochondria of renal epithelial cells during excretion of cisplatin metabolites through renal tubules and further forms a cisplatin–glutathione (GSH) complex, which ... chinese buffet hawthorne njWebThe widespread damage to the seminiferous epithelium induced by cisplatin administration was less severe in mice simultaneously treated with ghrelin. Furthermore, ghrelin … chinese buffet hazleton paWebIndeed, GSH can bind cisplatin forming cisplatin-GSH adducts which are exported from the cells through the multidrug resistance protein-2 (MRP-2) efflux pump, thus reducing the intracellular ... grand crystal theater wisconsin dellsWebJul 29, 2024 · Glutathione (GSH) is the most abundant non-protein thiol in cells and plays a critical role in maintaining intracellular redox homeostasis. 1 Alterations in glutathione levels are associated with several cellular … grand cubzaguais cdcWebMar 13, 2006 · Cisplatin is one of the most widely used chemotherapeutic drugs for treating cancer. Initially, platinum-based therapies are very effective in treating a wide array of cancers; however, recurrence and … grand crystal cave kyWebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … grand crystal seafood restaurant burnabyWebJan 15, 2024 · Cisplatin is a chemotherapeutic agent widely used to treat various malignancies, and its application is greatly limited due to its nephrotoxicity, including its onset of acute kidney injury (AKI) [ 1 ]. Undoubtedly, effective drugs to prevent cisplatin-induced AKI (Cis-AKI) in clinical practice are in urgent demand. chinese buffet hemel hempstead